Archive

Recent Results on Image Editing and Learning Filters

Abstract In the first part of this talk, I will present recent results on semantic-aware image editing. Skies are common backgrounds in photos but are often less interesting due to the time of photographing. Professional photographers correct this by using […]

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Learning Semantic Correspondence

Abstract I will present our recent approach to the problem of establishing semantic correspondences between images depicting different instances of the same object or scene category. Previous approaches focus on either combining a spatial regularizer with hand-crafted features, or learning […]

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Deciphering cell type-specific contributions of APOE4 to amyloid accumulation using iPSC-derived neural and glial cells

Abstract Despite APOE4 having the highest known risk for developing sporadic late-onset Alzheimer’s disease (AD), there is little information on how APOE4 variant impinges on the cellular functions of disparate cell types in the human brain, especially the astrocytes and […]

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Novel therapeutic target for TDP-43 proteinopathy: UPS impairment and beyond

Abstract UPS impairment has been implicated as a contributing factor in multiple human neurodegenerative diseases, such as Amyotrophic Lateral Sclerosis (ALS), Alzheimer’s disease (AD), and Parkinson’s disease (PD). Through an inhibitor screening of kinases that were upregulated in SOD1 ALS […]

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Large-scale Genetic Interaction Screen for the Discovery of Multiple Drug Targets

Abstract Genetic mutations are linked to a variety of human diseases. To understand how these genes contribute to disease, a reductionist approach is often used; a mutation in gene X causes dysfunction in protein X affecting pathway X to cause […]

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Novel views on brainstem structures and their functions and implications in neurodegenerative diseases

Abstract Despite the fundamental role of the brainstem in regulating vital functional abilities such as arousal, breathing, autonomic nervous system activity as well as regulating all higher cerebral functions via neurotransmitter projections systems originating in the brainstem, the role of […]

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Mechanism of disease progression in Parkinson’s disease

Abstract Synucleinopathies are neurological disorders, characterized by neuronal and glial deposition of a-synuclein aggregates. These disorders include Parkinson’s disease (PD), dementi with Lewy bodies, and multiple system atrophy. Cell-to-cell transmission of these aggregates are thought to be the underlying mechanism […]

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The Role of Mitochondria in Alzheimer’s Disease Pathogenesis

Abstract Mitochondria have been implicated in the pathogenesis of neurodegenerative diseases including Alzheimer’s disease (AD) and beta amyloid is found in the mitochondria, which interact with the proteins inside the organelles. To examine the role of mitochondria in AD pathogenesis […]

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Short-Term Synaptic Plasticity at a Glutamatergic Synapse

Abstract Synaptic Plasticity is held to be at the basis of most signal processing capabilities of the central nervous system. Long-term plasticity receives most attention by neuroscientists, since it underlies learning and memory. Short-term plasticity (STP), on the other hand, […]

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Opto-thermal Neural Interface Technology for Neuromodulation

Abstract Optical stimulation technology has become an attractive neuromodulation technique as it has potential benefit to provide high spatio-temporal resolution in controlling individual neurons. In addition, cell targeting is also possible by optogentics or functionalized nanoparticles. In this presentation, I […]

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