Archive

Autophagy deficiency in insulin target tissues leads to protection from obesity and insulin resistance by inducing “Mitokines”

Abstract:   Autophagy is an evolutionarily conserved process which delivers cytoplasmic components to lysosomes for degradation of aggregated proteins and damaged organelles such as mitochondria. To study the role of autophagy in insulin target tissues, we produced mice with deletion […]

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Single-Molecule Dynamics of Membrane Proteins under Mechanical Tension

Abstract:   More than one third of our genome encodes membrane proteins, which are essential gate keepers of cellular information. In spite of their importance in biological sciences, membrane proteins have largely evaded our efforts to observe their structure and […]

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The eye as a novel in vivo imaging site for pancreatic β-cells

Abstract:   One of the important challenges in cell biology/cell physiology/cell pathology and signal-transduction of today is to translate in vitro findings to the living organism. The insulin-secreting pancreatic β-cell is situated within the endocrine pancreas, the islets of Langerhans, […]

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Electrochemistry and Mass Spectrometry Imaging in Flies, Cells, and Vesicles

Abstract: Electrochemical methods provide a powerful approach to investigate neurotransmitter release and storage from and in single cells. Additionally, the fly model (Drosophila melanogaster) provides a unique system to examine neurotransmitter release and drug dependence mechanisms in a small, but […]

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Neuronal circuits underlying mouse social behaviors

Abstract: Emotional behaviors are associated with internal states that are perceived in humans as feelings. Aggression and sexual behavior are highly conserved, prototypic emotional behaviors that proceed through a series of appetitive and consummatory phases associated with increasing levels of […]

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T-type Ca2+ channels in motor coordination

Abstract: Specific behavioral patterns are determined by the complex coordination of muscle excitation and relaxation. Tremor, which is characterized by rhythmic muscle contractions, is one of the simplest types of motor coordination, and has been the focus of studies on […]

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The roles of Drosophila DJ-1 in neural sensitivity to stress

Abstract:   DJ-1 is an antioxidant protein that has been implicated in autosomal recessive Parkinson’s disease (PD), although the mechanism by which DJ-1 deficiency causes PD remains elusive. Drosophila DJ-1 mutants are highly sensitive to oxidative stress and UV irradiation, […]

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Mitochondrial Quality Control in the Nervous System

Abstract:   Mitochondria perform a number of essential cellular functions, but their damage can lead to bioenergetic failure and the release of cytotoxins that are implicated in aging and in neurodegenerative disease. Fortunately, eukaryotes have evolved a number of cellular […]

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Neuroimmunity and Autism Spectrum Disorder

Abstract:   All data acquired over the last two decades indicate that Autism Spectrum Disorder (ASD) has multiple causes. While genetic factors have been implicated in about 50% of the etiologies of ASD, it is likely that environmental factors are […]

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Novel Nanomaterials for a Green and Sustainable Future Energy

Abstract : To achieve a drastic CO2 reduction in the world, the realization of electric vehicles and energy network systems are essential. For the further progress in the development of polymer electrolyte fuel cells, their materials require to be controlled […]

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