Archive

Large-scale Genetic Interaction Screen for the Discovery of Multiple Drug Targets

Abstract Genetic mutations are linked to a variety of human diseases. To understand how these genes contribute to disease, a reductionist approach is often used; a mutation in gene X causes dysfunction in protein X affecting pathway X to cause […]

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Novel views on brainstem structures and their functions and implications in neurodegenerative diseases

Abstract Despite the fundamental role of the brainstem in regulating vital functional abilities such as arousal, breathing, autonomic nervous system activity as well as regulating all higher cerebral functions via neurotransmitter projections systems originating in the brainstem, the role of […]

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Mechanism of disease progression in Parkinson’s disease

Abstract Synucleinopathies are neurological disorders, characterized by neuronal and glial deposition of a-synuclein aggregates. These disorders include Parkinson’s disease (PD), dementi with Lewy bodies, and multiple system atrophy. Cell-to-cell transmission of these aggregates are thought to be the underlying mechanism […]

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The Role of Mitochondria in Alzheimer’s Disease Pathogenesis

Abstract Mitochondria have been implicated in the pathogenesis of neurodegenerative diseases including Alzheimer’s disease (AD) and beta amyloid is found in the mitochondria, which interact with the proteins inside the organelles. To examine the role of mitochondria in AD pathogenesis […]

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Short-Term Synaptic Plasticity at a Glutamatergic Synapse

Abstract Synaptic Plasticity is held to be at the basis of most signal processing capabilities of the central nervous system. Long-term plasticity receives most attention by neuroscientists, since it underlies learning and memory. Short-term plasticity (STP), on the other hand, […]

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Opto-thermal Neural Interface Technology for Neuromodulation

Abstract Optical stimulation technology has become an attractive neuromodulation technique as it has potential benefit to provide high spatio-temporal resolution in controlling individual neurons. In addition, cell targeting is also possible by optogentics or functionalized nanoparticles. In this presentation, I […]

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Recapitulation of Concentration Gradient and Mechanical Strain in Tissue in Vitro using Microfabricated Chip

Abstract Due to recent advances in microfabricated cell culture technology, the ability to realistically simulate important biological steps in disease models including cancer has dramatically improved. In particular, the capability to reproduce the niche of cancers in stem cells and […]

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Bio-analytical Devices for Human Healthcare and Environmental Monitoring

Abstract Recent developments in nano/micro technology have made it possible to construct small-scale bio-analytical devices for the analysis of biological markers such as nucleic acids, proteins, small molecules, and cells. Circulating tumor cells (CTCs) are highly correlated with the invasive […]

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Microfluidic technology for Biofabrication

Abstract Living materials show superior functions to the artificial ones in terms of the ability to recognize/produce biomolecules. For example, cells (in particular membrane proteins) achieve highly-sensitive and selective detection of several chemicals at the molecular level; they can even […]

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4th Industrial Revolution and Biopharmaceuticals

Abstract Of the new industries of the Fourth Industrial Revolution including artificial intelligence(AI), robot, virtual reality (VR), internet of things (IoT), bio, three-dimension (3D) and printing, scientists expects bio-industry, which is closely related to productivity, health and welfare of human […]

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