Archive

Site-Selective C–H Bond Oxidation Catalyzed by Mononuclear Nonheme Iron Complexes: Additive Effects of Carboxylic Acids

Abstract Development of selective C−H oxidation catalysts under mild conditions is strongly desired because of the application for the synthesis of complicated organic compounds. A possible approach to this purpose is to mimic biological systems, because some enzymes are capable […]

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Biomimetic Metal-Oxygen Intermediates in Dioxygen Activation Chemistry

Abstract Dioxygen is essential in life processes, and enzymes activate dioxygen to carry out a variety of biological reactions. One primary goal in biomimetic research is to elucidate structures of reactive intermediates and mechanistic details of dioxygen activation and oxygenation […]

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Biomimetic Intermediates in Dioxygen Activation

Abstract The dioxygen activation at the catalytic sites of the enzymes occurs through several steps including the binding of O2 at a reduced metal center, the generation of metal-superoxo and -peroxo species, and the O-O bond cleavage of metal-hydroperoxo complexes […]

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Biomimetic Metal-Oxygen Intermediates in Dioxygen Activation Chemistry

Abstract In the type 3 (T3) copper proteins of biological systems, the coupled dicopper active site reacts with O2 to form the peroxo intermediate species for O2 transportation and substrate oxygenation.  In multicopper oxidases (MCO), the clustering tricopper active site […]

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Physiological Responses to Biotic and Abiotic Stresses through Metalloenzymes

Abstract Tristetraprolin (TTP) uses three cysteine and one histidine residues to bind zinc ions. TTP regulates the expression of cytokines such as tumor necrosis factor α (TNF- α) by binding to AU-rich sequence elements (AREs) located at the 3’-untranslated region […]

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Formally Copper(III) Complexes Relevant to Oxidizing Intermediates in Enzymes

Abstract Characterization of copper intermediates in enzymes and other catalysts that attack strong C-H bonds is important for unraveling oxidation catalysis mechanisms and, ultimately, designing new, more efficient catalytic systems. New insights into the nature of such intermediates may be […]

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Embracing Industrial 4.0 – The Role of Robotics and AI

Abstract Industry 4.0 is transforming the future of industry and manufacturing towards smart factories with increased digitisation, automation and integrated control systems. The development of robotics, AI and Internet of Things (IoT) has played an important role in supporting this […]

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Functional Relevancy to Sports Rehabilitation

Abstract : The numbers of participants in sports and physical activity have been increasing as the importance of exercise are being emphasized for a better health and disease prevention. It seems apparent that the numbers of injuries among those who are […]

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Survive or Thrive: Tradeoff Strategy of Cellular Senescence

Abstract : The aging dependent cellular behaviors toward extrinsic stress are characterized by the confined localization of the certain molecules either to nuclear or perinuclear regions. Most of the growth factors can activate the downstream signals of the aging cells but […]

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Highly Efficient TiO2-X via Magnesiothermic Reduction for SunLight-Induced H2 Generation

Abstract : High efficiency with stable performance and utilization of visible light is a key challenge to sunlight-induced photochemical generation of H2, the cleanest energy carrier, using particulate photocatalyst system. Recently, black TiO2-x materials were achieved by creating oxygen vacancies […]

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