The scope of biological research has been severely restrained by the absence of the ultrasensitive, chemically-selective and sub-diffraction-limit-resolving optical microscope. To date, the stimulated emission depletion (STED) microscopy has been the strongest candidate to resolve the desire for a “perfect” microscope; however, it still relies on the tagging of the fluorescent particles to the analytes. Thus, scientists intend to develop a far field nano-optical imaging method without requiring any staining. To get this end, we first seek an optical modality which extracts intrinsic chemical/materials specific contrasts from the objects; the coherent Raman microscopy has offered the closest solution to this challenge. The diverse features of this talk concerning Raman-based spectro/microscopy will include the introduction of the new concepts, several technical development and critical upcoming prospects.
Coherent Raman imaging, nonlinear/adaptive optics, nano/bio materials, super-resolution microscopy
- Daegu Gyeongbuk Institute of Science and Technology, Senior Researcher, Nano-bio Research Division: Present
- Korean Research Institute of Chemical Technology, Research Scientist, Laboratory for Advanced Molecular Probing
- National Institute of Standards and Technology, Research Associate, Surface and Interface Research Group
- University of California-Irvine, Ph.D, Physical Chemistry
- University of Wisconsin-Madison, MS, Materials Science Program
- Pohang University of Science and Technology, BS, Materials Science and Engineering.
- Kim, H., Bryant, G.W., and Stranick, S.J. (2012) Optics Express 20, 6042-6051.
- Kim, H., Herzing, A., Michaels, C.A., Bryant, G.W., and Stranick, S.J. (2011) Nanoscale 3, 4290-4295
- Kim, H., Sheps, T., Collins, P.G., and Potma, E.O. (2009) Nano Lett. 9, 2991-2995.
- Kim, H., Taggart, D.K., Xiang, C., Penner, R.M., and Potma, E.O. (2008) Nano Lett. 8, 2373-2377.
- Fang, S., Lee, H.J., Wark, A.W., Kim, H., Corn, R.M. (2005) Anal. Chem. 77, 6528-6534.
Awards and Honors:
- 2009 University of California-IrvineDissertation Fellowship