Speakers

Towards High Density Polymer Neural Probe Arrays

d632ead86203c0ec186cf66fd5fa9729
Ellis Fan Chuin Meng
University of Southern California
Nov. 30 13:40~14:10

Abstract

Reliable chronic electrophysiological recordings remain elusive due to persistent biological failure affecting the electrode-tissue interface.  While large scale recordings (>100 channels) have been demonstrated using microwire and silicon-based intracortical electrodes, the rigidity of such construction risks further damage to soft neural tissue that elicits chronic immune response and the associated glial encapsulation.  Soft polymer construction reduces the mechanical mismatch by two orders of magnitude, however, polymer neural probe technology has lagged behind that of silicon in electrode density per shank and integration with microelectronic circuitry.  Through advances in polymer micromachining, we demonstrated multi-electrode probes and probe arrays comprising thin shanks of poly(para-chloro-xylylene) (Parylene C) integrated with a high density of platinum recording sites.  These devices were successfully deployed for deep brain recordings in the hippocampus with minimal immune response owing to the thin, flexible substrate, and a novel insertion method that obviates the need for bulky insertion shuttles or stiffening agents.  Overall, these technical advances seek to achieve large-scale, high-density arrays of polymer-based neural probes for chronic large scale recording of neural activity.

 

Education

  • 2003.01, Doctor of Philosophy, Electrical Engineering
    California Institute of Technology, Pasadena, CA
    Thesis Advisor: Yu-Chong Tai, Ph.D.
    Thesis Title: MEMS Technology and Devices for a Micro Fluid Dosing System
  • 1998.06, Master of Science, Electrical Engineering
    California Institute of Technology, Pasadena, CA
  • 1997.06, Bachelor of Science with Honors, Engineering and Applied Science
    California Institute of Technology, Pasadena, CA

 

Professional Career

  • 2015.07-Present, University of Southern California Los Angeles, CA
    Dwight C. and Hildagarde E. Baum Chair, Department of Biomedical Engineering
  • 2013.11-Present, University of Southern California Los Angeles, CA
    Director, Biomedical Microsystems Laboratory
    Professor, Department of Biomedical and Electrical Engineering
  • 2010.07-2015.07, University of Southern California Los Angeles, CA
    Chair, Women in Science and Engineering Program, Viterbi School of Engineering
  • 2010.04-2013.11, University of Southern California Los Angeles, CA
    Director, Biomedical Microsystems Laboratory
    Associate Professor, Department of Biomedical and Electrical Engineering
  • 2004.07-2010.04, University of Southern California Los Angeles, CA
    Director, Biomedical Microsystems Laboratory
    Assistant Professor, Department of Biomedical and Electrical Engineering
    Viterbi Early Career Chair
  • 2004.01-2004.06 Berkeley Sensor and Actuator Center, University of California Davis, CA
    Assistant Director

 

HONORS AND AWARDS

  • 2015, Orange County Engineering Council Distinguished Engineering Merit Award
  • 2014, Fellow, American Institute for Medical and Biological Engineering (AIMBE)
  • 2014, American Society for Engineering Education, Engineering Research Council – Curtis W. McGraw Research Award
  • 2013, 2nd Place Student Paper Award, IEEE EMBS Neural Engineering Conference
  • 2013, California Dreamin’ Business Plan Competition, 3rd place award
  • 2013, Member, Phi Tau Phi Scholastic Honor Society of America
  • 2013, Maseeh Entrepreneurship Prize Competition 1st place Alumni Choice Award
  • 2013, Best Poster Award, 7th International Conference of Microtechnologies in Medicine and Biology
  • 2013, USC Mellon Mentoring Culture of Mentoring Award
  • 2012, Medical Device and Diagnostic Industry’s MedTech 40 under 40
  • 2011, Viterbi School of Engineering Use-Inspired Research Award
  • 2011, NSF I-Corps (Innovation Corps) Award (first class)
  • 2011, TATRC/Qualcomm Wireless Health Innovation Challenge Winner
  • 2009, IEEE Senior Member