From Centenarian to semisupercentenarian and supercentenarian study

N_01_Nobuyoshi Hirose(photo)
Nobuyoshi Hirose
Keio University

Abstract :

We started centenarian study in 1992, to know the biomedical characteristics of centenarian. During this first wave study, we found the centenarian is a fascinating people who experienced many life events, sometimes sad and sometime happy. We thought that we must assess centenarian with not only biomedical, but also multidisciplinary approach. So we started multidisciplinary centenarian study in Tokyo metropolitan area (Tokyo Centenarian Study) from 2000 to 2004. Then we changed our target from centenarian to semisupercentenarian (SSC) and supercentenarian (SC), Japan semisupercentenarian study (JSS) was started from 2002 and still on going. Since SSC and SC was so rare, we recruited SSC and SC from whole Japan. So far we recruited over 700 SSC (including 130 SC). Our presentation is based on the results of TCS and JSS.

The aims of TCS and JSS are, 1) to characterize the phenotype of human aging, 2) to identify the factors associated with happy and healthy aging. These aims are same as geroscience.

Brief summary of TCS and JSS is 1) low prevalence of atherosclerosis and DM, 2) low albumin level, suggesting the presence of malnutrition, 3) high level of CRP and 4) nutrition and inflammation is associated with each other.

Then we measured leucocyte telomere length(LTL) in over 1500 the oldest old, including 160 offsprings of centenarians, 500 85+, 650 centenarians and SSC. LTL declines linearly till 100 years. But after 100 years, LTL is preserved. Life expectancy of 85+, centenarians and SSC is associated with inflammation, but not LTL. The mechanism of inflammation associated with aging may be fascinating topics of the research.

Whole genome sequencing of 100 SC and 300 SSC is in progress. We would like to present preliminary result of our WGS.

Finally we would like to present our future plan of research.

Now the advance of biotechnology is amazing. We think the secret of healthy aging will be disclosed soon. Centenarian study is very fascinating and fruitful research area.

We hope young scientists actively participate in centenarian study.



Graduated from Keio University School of medicine in 1973
National board of medical doctor in 1973
PhD from Keio University School of Medicine in 1988
Director of Geriatric medicine, Department of Internal Medicine, Keio University School of Medicine from 2003 till 2014
Retired from Keio University School of Medicine in 2014
Guest professor Center for supercentenarian research, Keio University School of Medicine from 2014 to present
He got his PhD from Keio University School of Medicine by the study of lipoprotein metabolism and atherosclerosis in 1988.
He started centenarian study from 1992, This study focused only to the biomedical aspect of centenarian. In 1997, he became an active member of International centenarian consortium (ICC) and prepared for the multidisciplinary, international centenarian study.
Based the discussion with other members of ICC, he started multidisciplinary centenarian study in Tokyo metropolitan area, collaborated with psychologists of Tokyo metropolitan institute of gerontology (TMIG). Tokyo centenarian study was conducted from 2000 till 2004. In 2002, he started Japan semisupercentenarian study(JSS). The target of this study is over 105+ (semisupercentenarian) and supercentenarian. This multidisciplinary study is conducted over 15 years.
His life-long interest is to identify the not only genomic, but also psychological factors related with happy and healthy longevity.
He was the PI of TCS and JSS. Since he retired from Keio University in 2014, Dr. Yasumichi Arai, his young colleague became new PI of both studies.
Dr. Arai actively continues JSS.