Speakers

On Tonic GABA and Glia-Neuron Interaction

Changjoon Justin Lee
Changjoon Justin Lee
KIST, Korea
15:00~15:45, November 21st, 2014

Abstract :

GABA is the major inhibitory transmitter in the brain. GABA is known to be released from GABA synthesizing neurons by Ca2+-dependent exocytosis of GABA-containing synaptic vesicles. However, this mechanism cannot explain the role of tonic inhibition by tonically released GABA. Recently we have demonstrated that GABA can be synthesized by astrocytes under physiological condition as well as pathological condition and released through Best1 channels. The tonically released astrocytic GABA can exert a profound inhibitory effect on neighboring neurons. It has been estimated that tonic GABA can exert over 70% of total inhibition in cerebellar granule neurons. Therefore, glia-derived tonic GABA is expected to have multiple roles in network activity, synchrony, and brain rhythms. In this talk, I will present an overview of the latest findings on the biosynthetic pathway and release mechanism of glia-derived GABA and its potential role in network activity.

 

Awards and Honors

  • 2013. 12. 20 : The University of Science & Technology, Star Professor Award
  • 2013. 08. 27: The University of Science & Technology, Outstanding Mentor Award
  • 2012. 12. 20: The University of Science & Technology, Best Mentor Award
  • 2011. 06. 29 : The University of Science & Technology, Best Mentor Award
  • 2011. 06. 29 : The University of Science & Technology, Outstanding Mentor Award
  • 2011. 02. 10 : KIST, Scientist of the Year Award
  • 2011. 02. 10 : KIST, Outstanding Research Team Award
  • 2010. 12. 31 : Outstanding Researcher Award, Prime Minister of Korea
  • 2010. 12. 29 : Scientist of the Month Award, Ministry of Science & Technology, Korea
  • 2010. 12. 02 : KIST, Scientist of the Month Award
  • 2009. 12. 21 : KIST, Outstanding Project Award
  • 2009. 06. 23 : The University of Science & Technology, Outstanding Teacher Award
  • 2009. 05. 26 : The University of Science & Technology, Outstanding Mentor Award
  • 2009. 02. 10 : KIST, Outstanding Researcher Award
  • 2008-Present : Editorial Board & Managing Editor, Molecular Brain
  • 2004-Present : Editorial board, Molecular Pain
  • 2003. 11. 11 : Association of Korean Neuroscientists Outstanding Researcher Award
  • 2000. 11. 07 : Association of Korean Neuroscientists Outstanding Researcher Award
  • 1996 : Society for Neuroscience, member since 1996
  • 1985 : National Honors Society
  • 1985-1989 : Illinois State Scholarship