Recapitulation of Concentration Gradient and Mechanical Strain in Tissue in Vitro using Microfabricated Chip

Sungsu Park
Sungkyunkwan University
Dec. 1 10:35~11:10


Due to recent advances in microfabricated cell culture technology, the ability to realistically simulate important biological steps in disease models including cancer has dramatically improved. In particular, the capability to reproduce the niche of cancers in stem cells and cancer in 3D microfluidic cell culture devices resulted in in vitro models of solid tumors that offer considerable advantages in many respects than conventional experiments in vitro.

In this talk, I will present my recent works in microfabricated simulation of various in vivo conditions including drug-resistance [1], cyclic stretching [2], and multi-organ interaction [3]. These works demonstrate that miniaturized cell culture system is an alternative to existing 2D culture models for cell biologists as well as medical researchers who are interested in understanding complex cell behaviors in an in-vivo like condition.



  • 1997-1999, Ph.D. Food Science, Cornell University, Ithaca, USA
  • 1994-1997, M.Sc. Food Science, Cornell University, Ithaca, USA
  • 1987-1994, B.Sc. Microbiology, Pusan National University, Pusan, Korea


Professional Career

  • 2014-Present, Professor, School of Mechanical Engineering, Sungkyunkwan University, Korea
  • 2008-2014, Associate/Full Professor, Dept. of Chemistry and Nano Sciences, Ewha Womans University, Seoul, Korea
  • 2010-2015, Co-Principal Investigator, Mechanobiology Institute (MBI), National University of Singapore (NUS), Singapore
  • 2004-2008, Assistant Professor, Division of Nano Sciences, Ewha Womans University, Korea
  • 2001-2004, Post-doc., Department of Physics, Princeton University, USA
  • 2000-2001, Post-doc., Department of Bioengineering, Cornell University, USA
  • 1999-2000, Post-doc., Department of Biological Information, Tokyo Institute of Technology, Japan