Brain Mapping and Systems Neuroscience

On Tonic GABA and Glia-Neuron Interaction

Abstract : GABA is the major inhibitory transmitter in the brain. GABA is known to be released from GABA synthesizing neurons by Ca2+-dependent exocytosis of GABA-containing synaptic vesicles. However, this mechanism cannot explain the role of tonic inhibition by tonically […]

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In search of the Molecular Basis of Major Depression and Antidepressants

Abstract : Major depressive disorder (MDD) is a chronic, recurrent, and even life-threatening mental disease, which affects up to 20 % of the population worldwide. Despite intense research over several decades, our understanding of the pathophysiology of this disease, as […]

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Synaptic Sensing and Modulation by Microglia: A Role in Neurodegeneration

Abstract : Microglia, the immune glia of the brain, are known to be dynamic cells constantly surveying the health of the surrounding tissue and responding to damage with rapid process extension.  In addition microglia processes are responsible for pruning synapses […]

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Clustered Thalamocortical Input on to Layer 5 Pyramidal Neurons

Abstract : The subcellular locations of synapses on pyramidal neurons strongly influence dendritic integration and synaptic plasticity. Despite this, there is little quantitative data on spatial distributions of specific types of synaptic input. Here we use array tomography (AT), a […]

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Neuronal Oscillations and Temporal Odor Coding

Abstract : Odor information is represented by both intensity and timing of neuronal activity in the olfactory bulb, but origins and roles of the temporal pattern remain enigmatic. Here we addressed this issues using two-photon calcium imaging of the mouse […]

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