Neurobiology with Model Animals

Neuronal circuits underlying mouse social behaviors

Abstract: Emotional behaviors are associated with internal states that are perceived in humans as feelings. Aggression and sexual behavior are highly conserved, prototypic emotional behaviors that proceed through a series of appetitive and consummatory phases associated with increasing levels of […]

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T-type Ca2+ channels in motor coordination

Abstract: Specific behavioral patterns are determined by the complex coordination of muscle excitation and relaxation. Tremor, which is characterized by rhythmic muscle contractions, is one of the simplest types of motor coordination, and has been the focus of studies on […]

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The roles of Drosophila DJ-1 in neural sensitivity to stress

Abstract:   DJ-1 is an antioxidant protein that has been implicated in autosomal recessive Parkinson’s disease (PD), although the mechanism by which DJ-1 deficiency causes PD remains elusive. Drosophila DJ-1 mutants are highly sensitive to oxidative stress and UV irradiation, […]

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Mitochondrial Quality Control in the Nervous System

Abstract:   Mitochondria perform a number of essential cellular functions, but their damage can lead to bioenergetic failure and the release of cytotoxins that are implicated in aging and in neurodegenerative disease. Fortunately, eukaryotes have evolved a number of cellular […]

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Neuroimmunity and Autism Spectrum Disorder

Abstract:   All data acquired over the last two decades indicate that Autism Spectrum Disorder (ASD) has multiple causes. While genetic factors have been implicated in about 50% of the etiologies of ASD, it is likely that environmental factors are […]

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