Archive

Neurodegeneration and Aging

Systems Biology of Plant Senescence and Death: How do plants know when to die and how to die?

Abstract: As we see from the death of whole rice field in autumn and of autumn leaves, plants and their organs age, senesce and die. Plant senescence is one of the most magnificent developmental events that we encounter in nature […]

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Humoral control of proteostasis -pathways towards longevity

Abstract: As an organism ages, its proteins face an increasing severity in the challenges they receive from extrinsic and intrinsic environmental perturbations (1, 2). Chaperones become dysregulated, while the degradation machineries stop working properly. The protein accumulates damage and starts […]

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Autophagic Cell Death Survives

Abstract:   Programmed cell death plays a fundamental role in human health and disease. Apoptosis-based approaches for neurodegenerative diseases often fail to yield neuroprotection, due to non-apoptotic forms of cell death and plasticity in switching between distinctcell death pathways. A […]

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Autophagy in Health and Disease

Abstract:   Autophagy is an evolutionarily-conserved catabolic process initiated by the engulfment of cytosolic components in a crescent-shaped structure, called phagophore that expands and fuses to form a closed double-membrane vesicle, the autophagosome. Autophagosomes are subsequently targeted to the lysosome/vacuole […]

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The role of mitochondria and sensory neurons in the longevity of C. elegans

Abstract: Many genetic factors that regulate organismal aging have been identified by using C. elegans as a model system. For example, reduced mitochondrial respiration or inhibition of sensory neurons confers longevity in C. elegans. Remarkably, these factors have been shown […]

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Progress Toward Brain Repair : Exploring mTORFunction on Stem Cell and Neurogenesis

Abstract: Neural stem cells (NSCs) lie at the core of brain development and repair, and alterations in NSC self-renewal anddifferentiation can have major consequences on brain function at any stage of life. As a result, a series of extracellular signals […]

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Spontaneous Formation of Oligomers and Fibrils in Large Scale Molecular Dynamics Simulations of Peptides

Abstract: Protein aggregation is associated with serious and eventually-fatal neurodegenerative diseases including Alzheimer’s and Parkinson’s. While atomic resolution molecular dynamics simulations have been useful in this regard, they are limited to examination of either oligomer formation by a small number […]

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Neuronal Atrophy, In-between Life and Death

Abstract: Programmed cell death (PCD) of neurons has long been considered to be essential for development and function of nervous system. However, Bax-deleted animals with a complete prevention of PCD can form normal neural circuitry and exhibit normal behavior. This […]

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Hexosamine metabolites enhance protein quality control and longevity

Abstract: Ageing is a major risk factor for numerous diseases, including neurodegeneration, which can result from a progressive decline in cellular protein homeostasis. We have recently discovered that activation of the hexosamine pathway (HP) through gain-of-function (gof) mutations in glucosamine-fructose […]

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Optogenetic Mapping of Brain Circuity

Abstract: Although the basic anatomy and cellular components of the brain have been known for more than a century, we still do not understand how the brain works. This is in large part due to technical limitations in our ability […]

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